Description
What is Lucigil 40 mg used for?
Lucigil 40 mg is a brand of Gilteritinib, a targeted FLT3 inhibitor used to treat adults with acute myeloid leukemia (AML) that has a FLT3 mutation and is relapsed (has come back) or refractory (did not respond to earlier treatment). It works by blocking the faulty FLT3 signal that drives leukemia cells to multiply. The usual dose is 120 mg (three 40 mg tablets) once a day, continued as long as it keeps working and is tolerated. Gilteritinib is a prescription-only medicine taken under the care of a blood-cancer (haematology) specialist.
Key Facts
| Detail | Information |
|---|---|
| Brand name | Lucigil 40 mg |
| Generic / active ingredient | Gilteritinib 40 mg |
| Drug class | FLT3 inhibitor (targeted tyrosine kinase inhibitor) |
| Dosage form | Film-coated oral tablet |
| Strength | 40 mg per tablet |
| Primary use | Relapsed or refractory FLT3-mutated acute myeloid leukemia (AML) in adults |
| Usual dose | 120 mg (three 40 mg tablets) once daily |
| How to take | Swallow whole, once daily — do not crush or split |
| Originator brand | Xospata® (Astellas) |
| Prescription status | Prescription only (Rx) |
| Storage | Store at room temperature, in original pack, away from moisture & children |
How Lucigil Works
In FLT3-mutated AML, a faulty gene called FLT3 sends out constant “grow and divide” signals that make leukemia cells multiply out of control.
Gilteritinib — the active ingredient in Lucigil — is a targeted FLT3 inhibitor. It blocks the FLT3 signal, helping to stop leukemia cells from multiplying and giving healthy blood cells a chance to recover.
In one line: Lucigil switches off the faulty FLT3 signal that drives FLT3+ leukemia to grow.
Uses
- Acute myeloid leukemia (AML) — in adults whose leukemia carries a FLT3 mutation and is relapsed or refractory (has returned after, or did not respond to, previous treatment). FLT3 mutation is confirmed by a lab test before starting.
Dosage & How to Take
- Usual dose: 120 mg — three 40 mg tablets — taken once a day, with or without food.
- Take it at about the same time each day. Swallow tablets whole with water — do not crush, chew or split them.
- It may take up to about 3–6 months of treatment to see a full response, so keep taking it as prescribed.
- Your doctor may pause, lower, or stop the dose if side effects occur, or adjust based on blood tests and ECGs. Never change the dose yourself.
- If you miss a dose, take it the same day as soon as you remember — but if it’s near the next dose, skip it. Do not double up.
Side Effects
Very common: muscle and joint pain, tiredness, raised liver enzymes, fever, low blood counts, constipation, diarrhoea, nausea, cough, swelling in the limbs, dizziness, and mouth sores.
Serious — get medical help promptly:
- Differentiation syndrome — fever, breathlessness, rapid weight gain/swelling, low blood pressure (can be life-threatening; usually managed with steroids).
- Heart rhythm changes (QT prolongation) — dizziness, fainting, or a fast/uneven heartbeat.
- PRES (a rare nervous-system problem) — seizures, severe headache, confusion, or vision changes.
Your doctor will monitor blood counts, liver function, and heart rhythm (ECG) during treatment.
Warnings & Precautions
- Watch for differentiation syndrome, QT prolongation and PRES (see above) — report symptoms immediately.
- Tell your doctor about all other medicines and supplements, as some can raise the risk of heart-rhythm problems or interact with Gilteritinib.
- Do not use during pregnancy — Gilteritinib can harm an unborn baby. Both men and women should use effective contraception during treatment and for a period after stopping, as advised by the doctor.
- Do not breastfeed during treatment and for two months after the last dose.
- Attend all scheduled blood tests and heart checks.
Storage
Store at room temperature in the original package, away from moisture. Keep out of the sight and reach of children. Do not use after the expiry date on the pack.
FAQ
What is Lucigil 40 mg?
Lucigil 40 mg is a brand of Gilteritinib, a targeted FLT3 inhibitor used to treat adults with relapsed or refractory FLT3-mutated acute myeloid leukemia (AML).
What is the generic name of Lucigil?
The generic name (active ingredient) is Gilteritinib. The internationally known originator brand is Xospata®.
How do I take Lucigil 40 mg?
The usual dose is 120 mg — three 40 mg tablets — once a day. Swallow the tablets whole with water; do not crush or split them. Always follow your haematologist’s instructions.
Is Lucigil chemotherapy?
No. Lucigil is a targeted therapy, not traditional chemotherapy. It blocks a specific leukemia driver (FLT3) rather than attacking all fast-dividing cells.
What are the main side effects of Lucigil?
Common effects include muscle/joint pain, tiredness, raised liver enzymes, fever and low blood counts. Serious but less common risks include differentiation syndrome, heart-rhythm changes (QT prolongation) and PRES — all monitored by your care team.
How long does Lucigil take to work?
A full response can take several months (often up to 3–6 months). Keep taking it as prescribed even before you notice a change.
Do I need a prescription to buy Lucigil 40 mg?
Yes. Lucigil is a prescription-only (Rx) cancer medicine and must be taken under the supervision of a specialist.
Can I take Lucigil during pregnancy?
No. Gilteritinib can harm an unborn baby. Effective contraception is required during treatment and for a period afterwards, as advised by your doctor.
Medical Disclaimer
This information is for general educational purposes only and is not a substitute for professional medical advice. Lucigil (Gilteritinib) is a prescription-only anti-cancer medicine. Always consult a qualified oncologist/haematologist or pharmacist before starting, stopping or changing treatment. Do not self-medicate.
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